Coexistence of thyroid disease and oral lichen planus in a Colombian population / Coexistencia de enfermedad de la tiroides y liquen plano oral en una población colombiana

Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease of unknown etiology. OLP has recently been linked to thyroid disease, mainly hypothyroidism. The aim of this study was to determine the prevalence of thyroid disease in Colombian patients with OLP. A total of860 clinical records of patients attending the clinics of oral medicine and oral and maxillofacial surgery at IPS CES Sabaneta, Colombia, between 2010 and 2016 were reviewed. Fourteen patients (1.6%) had a diagnosis of OLP. The prevalence of hypothyroidism in patients with OLP was 35.7%, compared to 3.95% in the entire study population (OR 15.92, 95% CI: 5.63-50.09, P = 0.0001). Patients with concomitant hypothyroidism and OLP presented with less severe oral lesions compared to those without thyroid disease. This study supports the notion that patients with OLP should be screened for thyroid disease.

El liquen plano oral (LPO) es una enfermedad mucocutánea inflamatoria crónica de etiología desconocida. El LPO ha sido asociado recientemente con la enfermedad de la tiroides, especialmente con hipotiroidismo. El objetivo con este estudio fue determinar la prevalencia de la enfermedad de la tiroides en pacientes colombianos con LPO. Un total de 860 historias clínicas de pacientes que asistieron entre 2010 y 2016 a las clínicas de medicina oral y de cirugía oral y maxilofacial de la IPS CES Sabaneta, Colombia, fueron revisadas. Catorce pacientes (1.6%) habían sido diagnosticados con LPO. La prevalencia de hipotiroidismo en pacientes con LPO fue 35.7%, comparada con 3.95% en toda la población de estudio (RM 15.92, 95% IC: 5.63-50.09, P = 0.0001). Pacientes con hipotiroidismo y LPO concomitante presentaron lesiones orales menos severas comparado con aquellos sin enfermedad de la tiroides. Este estudio respalda la idea de que se debe investigar la presencia de enfermedad de la tiroides en pacientes con LPO.

Potentially malignant oral lesions: clinicopathological correlations / Lesões orais potencialmente malignas: correlações clínico-patológicas

ABSTRACT Objective To determine the incidence of potentially malignant oral lesions, and evaluate and correlate their clinical and pathological aspects. Methods The sample consisted of cases clinically diagnosed as oral leukoplakia, oral erythroplakia, erythroleukoplakia, actinic cheilitis, and oral lichen planus treated at a diagnostic center, between May 2012 and July 2013. Statistical tests were conducted adopting a significance level of 5% (p≤0.05). Results Out of 340 patients, 106 (31.2%) had potentially malignant oral lesions; and 61 of these (17.9%) were submitted to biopsy. Actinic cheilitis was the most frequent lesion (37.5%) and the lower lip was the most affected site (49.6%). Among 106 patients in the sample, 48 (45.3%) reported nicotine consumption, 35 (33%) reported alcohol intake and 34 (32.1%) sun exposure while working. When clinical and histopathological diagnoses were compared, oral erythroplakia and atypical ulcer were the lesions that exhibited greater compatibility (100% each). Conclusion In most cases, clinical and histopathological diagnoses were compatible. An association between the occurrence of erythroplakia, leukoplakia and erythroleukoplakia with smoking was observed. Similarly, an association between actinic cheilitis and sun exposure was noted. Erythroleukoplakia presented the highest malignancy grade in this study. Finally, dental surgeons should draw special attention to diagnosis of potentially malignant oral lesions, choose the best management, and control the lesions to avoid their malignant transformation.

RESUMO Objetivo Verificar a incidência das lesões orais potencialmente malignas, e avaliar e correlacionar seus aspectos clínico-patológicos. Métodos A amostra foi composta pelos casos diagnosticados clinicamente como leucoplasia oral, eritroplasia oral, eritroleucoplasia, queilite actínica e líquen plano oral em um serviço de diagnóstico no período entre maio de 2012 e julho de 2013. Foram realizados testes estatísticos adotando-se nível de significância de 5% (p≤0,05). Resultados Dos 340 pacientes examinados, 106 (31,2%) se apresentaram com lesões orais potencialmente malignas; destes, 61 (17,9%) biópsias foram realizadas. A lesão mais frequente foi a queilite actínica (37,5%), e o sítio anatômico mais acometido foi o lábio inferior (49,6%). Entre os 106 pacientes da amostra, 48 (45,3%) relataram consumo de nicotina, 35 (33%) ingeriam bebidas alcoólicas e 34 (32,1%) trabalhavam expostos ao sol. Comparando o diagnóstico clínico com o histopatológico, as lesões que apresentaram maior compatibilidade foram a eritroplasia oral e a lesão ulcerada atípica (100% ambas). Conclusão Na maioria dos casos, houve compatibilidade do diagnóstico clínico com o histopatológico. Notou-se correlação entre a ocorrência de eritroplasia, leucoplasia e eritroleucoplasia com o hábito de fumar, e entre a queilite actínica com a exposição solar. A eritroleucoplasia foi a lesão que demonstrou maior grau de malignização neste estudo. Diante do exposto, recomenda-se maior atenção por parte dos cirurgiões-dentistas ao diagnóstico das lesões orais potencialmente malignas, para aplicação da melhor conduta e controle da lesão, impedindo sua transformação maligna.

Contribution à l'étude des manifestations buccales du lichen plan

Introduction:Le lichen plan buccal est une dermatose inflammatoire chronique, Il touche d'avantage la peau et la muqueuse orale mais les phanères et les autres muqueuses peuvent être également touchées. L'objet de notre étude est de préciser les caractéristiques cliniques de la pathologie dans sa localisation buccale. Patients et méthode Le recrutement des patients s'est fait au service de pathologie bucco-dentaire du CHU Mustapha Ont été retenus les patients présentant une lésion évoquant cliniquement un lichen plan buccal. Tous les patients ont bénéficié d'un examen clinique, complété pour certains par un examen anatomo-pathologique. La saisie des données est faite sur le logiciel Epi Info 6.0 fr. Résultats 80 patients ont été recrutés entre Janvier 2009 et Juin 2015, Le taux de prévalence estimé de la maladie est de 0,11%. La pathologie est plus fréquente chez l'adulte entre 40 et 60 ans, avec une prédominance féminine. 63,75% des patients présentent des comorbidités notamment diabète (29,41%), HTA (47,05%), et 55% prennent un traitement médical de façon permanente et chronique, Le stress et l'état psychologique du patient ont été retenus comme facteurs déclenchant la maladie et exacerbant la symptomatologie. La forme réticulée est plus fréquente (78,75%) suivie par la forme érosive (53,75%), L'atteinte est dans 84% des cas bilatérale, La localisation jugale prédomine (88,75%), Le traitement médical reste à effet palliatif, nous avons noté un cas de transformation maligne (1,44%), chez une femme après 03 ans d'évolution d'un lichen plan érosif lingual. Conclusion Le lichen plan est une pathologie auto-immune chronique, dans sa localisation buccale pose un problème de diagnostic, le traitement médical reste palliatif, l'élimination des facteurs irritatifs locaux et la prise en charge psychologique des patients permettent de mieux gérer les symptômes et les poussées aigues. Le risque de transformation maligne existe et par conséquent un suivi régulier du malade s'impose

Oral Atrophic Lichen Planus: Diagnosis and Management.

Lichen planus is a chronic T-cell mediated autoimmune disease, which affects the oral mucosa, skin, genital mucosa, scalp and nails. Oral lichen planus, the mucosal counterpart affects 0.5-2.0% of the general population and often seen in the fifth to sixth decades of life. The lesion is frequently seen in women. Since it is considered a potentially malignant disorder, early diagnosis with timely management and regular follow-up is very important to avoid further complications. This paper reports a case of atrophic lichen planus, highlights the classic picture of atrophic lichen planus, discusses the differential diagnoses and timely management and follow-up.

Líquen plano oral: reconhecendo a doença e suas características básicas / Oral lichen planus: recognizing thedisease and its basic feature

Introdução: o Líquen plano é uma doença mucocutânea comum, crônica e inflamatória. A Organização Mundial da Saúde classificou o líquen plano como uma doença cancerizável mas de difícil identificação dos agentes etiológicos. Contudo, o consumo de bebidas alcoólicas, tabaco, fatores genéticos, agentes infecciosos e imunológicos devem ser levados em consideração no potencial de malignização. Objetivo: a proposição deste trabalho é relatar uma revisão literária atualizada sobre o Líquen Plano Oral (LPO) focada em bases de dados nacionais e internacionais (Pubmed, Bireme). Busca de forma sucinta, explicitar o conceito, dados epidemiológicos, características clínicas e histopatológicas do LPO, bem como seu potencial de carcinogênese e formas de tratamento. Revisão de literatura: todo cirurgião dentista deve ter conhecimento das diferentes formas de líquen plano oral, procurando reconhecer os aspectos lesionais que indicam alteração de normalidade, diagnosticar corretamente as patologias e buscar um tratamento adequado ao paciente portador dessa e outras lesões. Considerações finais: a forma erosiva do LPO é considerada a única que tem potencial de carcinogênese, sendo o diagnóstico precoce e o tratamento adequado essenciais para o sucesso do tratamento. -

Introduction: The Lichen planus is a common mucocutaneous disease, chronic and inflammatory. The World Health Organization ranked the lichen planus as a disease that can turn malignant in about 2-3 per cent but it is difficult to identify the etiologic agents. However, alcohol consumption, tobacco, genetic, infectious and immunological agents should be taken into account in the malignant potential. Objective: the purpose of this work, from a literature review on the topic of oral lichen planus (OLP) focused on bases of national and international databases (Pubmed, BIREME). Succinctly get the concept, epidemiological data, clinical features and histopathology of OLP) and its potential for carcinogenesis and its forms of treatment. Literature review: emphasizing that every dentist should have knowledge of different forms of oral lichen planus, seeking to recognize the lesional aspects that indicate change of normality, correctly diagnosing the disease and seeking a suitable for your patient with this treatment and other injuries. Final considerations: The erosive form of OLP is the only one that has potential for carcinogenesis, with early diagnosis and proper treatment essential for successful treatment.

Lichen Planus in Four Clinical Forms.

Lichen planus is an autoimmune disorder which comes under lichenoid reactions. It is T-cell mediated cytotoxic reaction directed against antigen expressed by basal cell layer of the oral mucosa. Autoreactive T-lymphocytes may be of primary importance for the development of oral lichen planus. Lichen planus presentations in the oral cavity are in 6 forms: Reticular, papular, plaque, bullous, erythematous and ulcerative. We present a case report of 4 forms in a patient.

Mucocutaneous manifestations in hepatitis C patients

To determine the frequency and nature of mucocutaneous manifestations in hepatitis C virus [HCV] positive patients. Two hundred and five HCV positive patients presenting at the outpatient and inpatient departments of Services Hospital, Lahore were evaluated for mucocutaneous manifestations. Relevant data regarding history, clinical examination including cutaneous system and investigations were documented and analyzed. Mean age of patients was 36.6 +/- 11.0 years. There were 84 [41%] males and 121 [59%] females. 73.7% cases were exposed to antiviral therapy. Dermatological manifestations were present in 88.3% patients with HCV infection. Pruritus was the most common finding seen in 39.5% followed by hyperpigmentation of skin 34.1%, lichen planus 18%, lingual/buccal pigmentation 13.2%, melanonychia 12.7% and urticaria 6.8%. Less frequent features were palmar erythema, photosensitivity and cutaneous vasculitis. Dermatological manifestations may appear as an earliest sign of hepatitis C infection. Therefore, vigilant detection and careful investigation can prevent the complications and further spread of this dreadful disease

Oral lichen planus and Hepatitis C virus infection: an epidemiological study of 149 cases / Liquen plano oral e infección del virus de la Hepatitis C: un estudio epidemiológico de 149 casos

The objective of this investigation was to assess the prevalence of oral lichen planus (OLP) in Moroccan patients infected with hepatitis C virus (HCV) from the Hepatology service of Ibn Sina University hospital of Rabat. The study group consisted of 149 patients with HCV infection. All patients with clinical features of OLP were submitted to the service of oral surgery for confirmation. Among the 149 HCV-infected patients of the study group, 35 patients had OLP which represents a prevalence of 23.5 percent. Two out of these 35 patients with OLP-HCV association had cutaneous lichen planus (CLP) as well. Our findings indicate that there is a significant association between OLP and HCV infection especially for reticular and erosive types of OLP.

El objetivo de esta investigación fue evaluar la prevalencia de liquen plano oral (LPO) en los pacientes marroquíes infectados con hepatitis C (VHC) del Servicio de Hepatología del Hospital Universitario Ibn Sina de Rabat. El grupo de estudio consistió de 149 pacientes con infección por el VHC. Todos los pacientes con características clínicas de LPO se presentaron al servicio de cirugía oral para su confirmación. Entre los 149 pacientes infectados por VHC del grupo de estudio, 35 pacientes presentaban LPO, una prevalencia de 23,5 por ciento. Dos de estos 35 pacientes con LPO asociado al VHC tenían también liquen plano cutáneo (LPC). Nuestros hallazgos indican que existe una asociación significativa entre la LPO y la infección por el VHC, especialmente para los tipos de LPO reticular y erosivo.

Estudo epidemiológico das doenças dermatológicas imunologicamente mediadas na cavidade oral / An epidemiological study of immune-mediated skin diseases affecting the oral cavity

FUNDAMENTO: As doenças dermatológicas imunologicamente mediadas compõem diversas patologias que apresentam formas variadas de manifestação no organismo. OBJETIVO: Foi proposição desta pesquisa, estabelecer a prevalência das principais doenças dermatológicas imunologicamente mediadas que apresentam manifestação oral. MÉTODOS: Foram avaliados laudos histopatológicos de 10.292 casos arquivados no Serviço de Anatomia Patológica da Disciplina de Patologia Oral da Universidade Federal do Rio Grande do Norte, no período de 1988 a 2009. Dos casos diagnosticados como algum tipo de doença em estudo, coletaram-se dados clínicos como sexo, idade, raça, sítio anatômico e sintomatologia das doenças. RESULTADOS: Do total de casos registrados, no serviço supracitado, 82 (0,8 por cento) corresponderam a doenças dermato lógicas imunologicamente mediadas com manifestação na cavidade oral. As doenças encontradas neste estudo foram: líquen plano oral, pênfigo vulgar e penfigoide benigno das membranas mucosas, sendo o líquen plano oral a lesão mais prevalente, representando 68,05 por cento dos casos analisados, dos quais 64,3 por cento apresentavam-se em mu lheres, sendo a mucosa jugal o sítio anatômico mais acometido (46,8 por cento). CONCLUSÃO: A ocorrência de doenças dermatológicas imunologicamente mediadas que apresentam manifestação oral ainda é um fato incomum, semelhante ao observado na maioria das regiões mundiais. No entanto, a busca pelo diagnóstico precoce é um requisito essencial para a condução do tratamento dessas doenças, tendo em vista o possível comprometimento sistêmico do organismo nos pacientes.

BACKGROUND: Immune-mediated skin diseases encompass a variety of pathologies that present in different forms in the body. OBJECTIVE: The objective of this study was to establish the prevalence of the principal immune-mediated skin diseases affecting the oral cavity. METHODS: A total of 10,292 histopathology reports stored in the archives of the Anatomical Pathology Laboratory, Department of Oral Pathology, Federal University of Rio Grande do Norte, covering the period from 1988 to 2009, were evaluated. For the cases diagnosed with some type of disease relevant to the study, clinical data such as the gender, age and ethnicity of the patient, the anatomical site of the disease and its symptomatology were collected. RESULTS: Of all the cases registered at the above-mentioned service, 82 (0.8 percent) corresponded to immune-media ted skin diseases with symptoms affecting the oral cavity. The diseases found in this study were: oral lichen planus, pemphigus vulgaris and benign mucous membrane pemphigoid. Oral lichen planus was the most common lesion, comprising 68.05 percent of the cases analyzed. Of these cases, 64.3 percent were women and the cheek mucosa was the anatomical site most commonly affected (46.8 percent). CONCLUSION: Immune-mediated skin diseases affecting the oral cavity continue to be rare, the prevalence found in this study being similar to that reported for the majority of regions worldwide. Nevertheless, early diagnosis is indispensable in the treatment of these diseases, bearing in mind that systemic involvement is possible in these patients.

Liquen plano oral y su relación con el desarrollo de carcinomas. Revisión bibliográfica: reporte de un caso / Oral lichen planus and its relation with the development of carcinomas. Review of the literature: a clinical case report

Se realizó la búsqueda bibliográfica de la incidencia del liquen plano oral y su relación con el desarrollo de carcinomas verrugoso y espinocelular en Sudamérica, que varía en relación con otras latitudes. Su mayor incidencia es en el sexo femenino, fuera de factores de riesgo, pero con un componente psicológico evidente. El caso clínico del presente trabajo es sobre una paciente de género femenino de 52 años de edad, diabética tipo dos e hipertensa compensada, quien presentaba dos lesiones de liquen plano que fueron biopsiadas, obteniéndose como resultado anatomopatológico carcinoma verrugoso y espinocelular.

prevalence of salivary gland disorders and lichenplanus in patients infected with chronic hepatitis C virus

This study was carried out to examine the oral health of Hepatitis C Virus infected patients. In particular, the prevalence of salivary glands disorders and Oral Lichen Planus. Eighty patients infected with HCV, who were not undergoing anti-viral treatment, were examined. The information collected from the patients included, demographic details together with perception of their oral health and access to dental care since they were diagnosed of hepatitis C. Both extra-oral and intra-oral examinations were conducted. Teeth present and visible caries were recorded, periodontal conditions were measured using a Community Periodontal Index of Treatment Need [CPITN] probe and denture fit and hygiene were assessed where appropriate. The soft tissues were examined and lichen planus was diagnosed clinically. The whole salivary flow rates were estimated using spitting technique. The oral health of this cohort was poor. Twelve patients had clinical evidence of oral lichen planus [OLP], though all were not confirmed histologically. The salivary flow rates were significantly lower [p < 0.001] than previously reported healthy controls. Of the 25 regular dental attenders, only 5 had encountered problems accessing dental care. Chronic HCV infected patients require significant oral health care and an effective oral health education is required for HCV-infected patients and their carers

Evaluation of median rhomboid glossitis and oral Lichen planus in patients with diabetes mellitus

Diabetes mellitus is one the most common endocrinopathies with many oral manifestations. Diabetic people form a large group of patients visited by dentists. The aim of this study was to evaluate the MRG and OLP in patients with diabetes types 1 and 2. This was a descriptive cross-sectional study carried out on a total of 428 patients including 148 cases with diabetes type 1, 124 with diabetes type 2 and 156 as control group in Qazvin University of Medical Sciences in 2001-2002. The study population was selected according to the selection criteria followed by oral examinations and completion of a questionnaire. The data were analyzed by SPSS soft ware, chi square and Fisher's exact tests. The prevalence of MRG in patients with diabetes types 1 and 2 and in control group was 4.2%, 3.2% and 1.2%, respectively [P < 0.0]. Also, the prevalence of OLP among the two diabetic groups and the control group was 4.7%, 4%, and 2%, respectively [p > 0.0]. Based on our results, there was a statistically significant difference between MRG and diabetes but no such relationship between OLP and diabetes was established

Asociación de liquen plano bucal con virus de hepatitis C en una muestra de la población venezolana / Association of oral lichen planus with hepatitis C virus in a Venezuelan population sample

El liquen plano es una enfermedad mucocutánea inflamatoria crónica que frecuentemente involucra la mucosa bucal. Recientes estudios han confirmado una asociación significativa entre el liquen plano bucal (LPB) y enfermedad hepática, en particular con la infección por Virus de la Hepatitis C (VHC). El objetivo del presente estudio fue evaluar la asociación del LPB en pacientes con infección por VHC. Se evaluaron 67 pacientes infectados por VHC detectados por anticuerpos anti-VHC mediante ensayo inmunoabsorbente ELISA (tercera generación), confirmado por trancriptasa reversa- reacción en cadena de la polimerasa (TR-RCP) VHC-ARN. Solo uno de los 67 pacientes positivos para VHC fue clínica e histológicamente positivo para LPB. En este trabajo concluimos que aunque se han reportado casos donde existe una asociación entre liquen plano bucal e infección por VHC, la asociación entre estas dos enfermedades no se observó en la población venezolana, debido posiblemente a que el origen geográfico y hábitos de los pacientes podría jugar un rol importante en la prevalencia de la infección por este virus y sus manifestaciones extrahepáticas, en pacientes con LPB.

Lichen planus is a chronic inflammatory mucocutaneous disease that frequently involves the oral mucosa. Recent studies have confirmed a significant association between oral lichen planus (OLP) and liver diseases, in particular with Hepatitis C virus (HCV) infection. The aim of this study was to evaluate the association of OLP in patients with HCV infection. We evaluated 67 patients with HCV infection detected for anti-HCV by immunosorbent assay ELISA (third generation) confirmed by reverse transcription polymerase chain reaction (RT-PCR) HCV-RNA Only one of 67 HCV positive patients was clinically and histologically positive for OLP. We concluded that although cases of oral lichen planus associated with hepatitis C virus (HCV) infection have been described, the association between the two diseases has not been established in the Venezuelan population, because the geographic origin of patients could play an important role in HCV prevalence in patients with OLP.

Prevalence of oral lesions in relation to habits: Cross-sectional study in South India.

BACKGROUND: Smoking, drinking and chewing tobacco product, common habits in India have been positively associated with oral lesions. No study has been conducted in this part of Tamilnadu regarding the prevalence of oral lesions in relation to habits. METHODS: A hospital based cross-sectional study was carried out at Ragas Dental College, Chennai. Already existing data of two thousand and seventeen consecutive patients from sub-urban areas of Chennai, who attended the outpatient department, at Ragas Dental College, for dental complaints during a period of three months in 2004, who underwent oral examination and interviewer based questionnaire was used. RESULTS: Oral soft tissue lesions were found in 4.1% of the study subjects. The prevalence of leukoplakia, OSF and oral lichen planus was 0.59%, 0.55%, and 0.15% respectively. The prevalence of smoking, drinking alcoholic beverages and chewing was 15.02%, 8.78% and 6.99% respectively. Smoking and chewing were significant predictors of leukoplakia in this population. DISCUSSION: The prevalence of leukoplakia, OSF and oral lichen planus in our study population is similar to those found in other populations. The prevalence of consumption of alcoholic beverages in our study population was higher when compared to the Indian National Sample Survey study. However the prevalence of smoking and chewing was found to be lower. Smokers were more likely to develop smoker's melanosis compared to other lesions. Among those who consumed alcoholic beverages alone, the prevalence of leukoplakia was higher compared to other lesions. OSF was the most prevalent lesion among those who chewed panmasala or gutkha or betel quid with or without tobacco.

Líquen plano bucal e hepatite C / Oral lichen planus and hepatitis C

O Líquen Plano bucal tem sido relacionado com o vírus da Hepatite C, com achados ainda inconclusivos, não estando, ainda estabelecida, se essa associação é real ou ocasional. Esse trabalho tem por objetivo revisar a literatura atual sobre a prevalência da relação entre o Líquen Plano bucal e a Hepatite C, com levantamento de dados e discussão crítica dos achados. Embora estudos surgiram uma asociação loco regional, a relação entre o Líquen Plano bucal e hepatite C não está, ainda totalmente estabelecida, sendo necessárias maiores investigações.

Oral lichen planus. Clinical aspects and management in fifty-two Brazilian patients

This study aimed to characterize the clinical profile of patients with oral lichen planus (OLP) and to evaluate the efficacy of topical, systemic and/or intralesional corticosteroids in the management of symptomatic cases. Fifty-two patients with OLP, 33 females and 19 males, aged from 17 to 75 years (mean 49.7 years) were studied. Information regarding the clinical forms, sites of involvement, patients' medical history and habits were recorded. Diagnosis of OLP was made using clinical criteria alone in 32 cases, while biopsy examination was required in the remaining 20. Symptomatic lesions were seen in 29 patients, who were treated with corticosteroid. Asymptomatic cases (23) were only clinically monitored. The forms of OLP found in this study were reticular (47), atrophic (24), erosive (21) and plaque-like (8). The buccal mucosa was the site predominantly affected. Systemic diseases were found in 17 patients (seven diabetic and ten with hypertension) but these data lacked statistical significance (p > 0.05) when compared with a control group of age and gender matched patients without any type of mucocutaneous disease. A habit of tobacco and/or alcohol use was reported by 11.5 of the patients, most of them with the reticular form of the disease. Topical corticosteroid therapy alone was effective in producing relief of symptoms in 18 of the 29 patients, although some relapses occurred after discontinuation. For lesions non-responsive to topical treatment, intralesional injection and/or short-term use of systemic corticosteroids were used

Oral lichen planus. Clinical aspects and management in fifty-two Brazilian patients

This study aimed to characterize the clinical profile of patients with oral lichen planus (OLP) and to evaluate the efficacy of topical, systemic and/or intralesional corticosteroids in the management of symptomatic cases. Fifty-two patients with OLP, 33 females and 19 males, aged from 17 to 75 years (mean 49.7 years) were studied. Information regarding the clinical forms, sites of involvement, patients' medical history and habits were recorded. Diagnosis of OLP was made using clinical criteria alone in 32 cases, while biopsy examination was required in the remaining 20. Symptomatic lesions were seen in 29 patients, who were treated with corticosteroid. Asymptomatic cases (23) were only clinically monitored. The forms of OLP found in this study were reticular (47), atrophic (24), erosive (21) and plaque-like (8). The buccal mucosa was the site predominantly affected. Systemic diseases were found in 17 patients (seven diabetic and ten with hypertension) but these data lacked statistical significance (p > 0.05) when compared with a control group of age and gender matched patients without any type of mucocutaneous disease. A habit of tobacco and/or alcohol use was reported by 11.5 of the patients, most of them with the reticular form of the disease. Topical corticosteroid therapy alone was effective in producing relief of symptoms in 18 of the 29 patients, although some relapses occurred after discontinuation. For lesions non-responsive to topical treatment, intralesional injection and/or short-term use of systemic corticosteroids were used

Estudo epidemiológico de lesöes bucais de líquen plano do laboratório de patologia bucal da Faculdade de Odontologia da Universidade Federal de Minas Gerais / Epidemiologic study of oral lichen planus from Oral Pathology Laboratory, School of Dentistry of Minas Gerais Federal University

O líquen plano (LP) é uma doença inflamatória mucocutânea crônica de aparecimento comum na populaçäo e provavelmente mediado por linfócitos T. Pode apresentar-se sob várias formas clínicas, o que dificulta o seu reconhecimento. Existem controvérsias na literatura sobre a possível associaçäo do LP com várias alteraçöes sistêmicas, e com o carcinoma epidermóide de boca. Objetivou-se, com esse trabalho, o levantamento retrospectivo dos dados epidemiológicos referentes aos casos de líquen plano bucal da Faculdade de Odontologia da UFMG, e a avaliaçäo da correlaçäo entre os diagnósticos clínicos e histopatológicos. O trabalho discute a necessidade de melhor conhecimento, pelo cirurgiäo-dentista, sobre as várias formas de apresentaçäo clínica desta alteraçäo, assim como a necessidade de estabelecimento do diagnóstico diferencial com outras lesöes que podem ser confundidas clinicamente com o LP

Prevalência do líquen plano bucal em pacientes brasileiros portadores de líquen plano cutâneo / Prevalence of oral lichen planus in Brazilian patients with cutaneous lichen planus

O líquen plano (LP) é uma doença mucocutânea de etiologia desconhecida, que afeta 0,5 a 2 por cento da populaçäo. Este estudo foi realizado para se determinar a prevalência de comprometimento bucal específico em pacientes brasileiros portadores de líquen plano cutâneo (LPC). Quarenta e cinco pacientes com LPC e 100 pacientes portadores de outras doenças (Grupo controle - GC) foram clinicamente examinados. Dos 45 pacientes portadores de LPC, 28 eram do sexo masculino (62,2 por cento) e 17, do sexo feminino (37,8 por cento). As idades do grupo LPC variaram de 4 a 74 anos, com média de 37,2 anos. No grupo controle, dos 100 pacientes portadores de outras doenças, 26 eram do sexo masculino (26 por cento) e 74 do sexo feminino (74 por cento). As idades do grupo controle (GC) variaram de 5 a 79 anos, com média de 36,1 anos. Os pacientes foram submetidos à exame clínico geral completo, exame dermatológico e bucal. Realizou-se exame histopatológico para confirmar os diagnósticos clínicos. Oitenta e seis, sete por cento (86,7 por cento) dos pacientes relataram estresse emocional como desencadeante da doença. Observou-se um aumento significativo no grupo LPC de doenças anteriores (LPC-88,9 por cento, GC-48 por cento), tabagismo (LPC-33,3 por cento, GC-17 por cento), etilismo (LPC-62,2 por cento, GC-14 por cento). História familiar para LP foi relatada em 11,3 por cento. Somente 22,2 por cento apresentavam LP bucal (reticular - 50 por cento; papular - 30 por cento; em placa - 20 por cento). Neste estudo, o comprometimento bucal específico foi menor do que o relatado na literatura. A importância deste estudo está no fato de que os pacientes procuraram o médico, devido ao comprometimento cutâneo, näo sabendo previamente se apresentavam comprometimento bucal simultâneo

Liquen plano en un niño: reporte de un caso / Lichen planus in a child: report of a case

Este es el reporte de un caso clínico de liquen plano en cara dorsal de lengua de un niño de 5 años de edad. Es interesante señalar que existen pocos reportes sobre estas enfermedades en niños, la mayor referencia es de lesiones en piel. En este caso, la aparición de esta lesión es posible que esté relacionada con la administración de doxicilina.